Anti-Thyrotropin Antibody Interference in Thyrotropin Assays
نویسندگان
چکیده
منابع مشابه
Interference in a radioimmunoassay for human thyrotropin.
Abnormally high plasma thyrotropin values were found by radioimmunoassay in some patients when an antiserum to porcine thyrotropin was used, normal results being obtained with an antiserum raised to human thyrotropin. These discrepancies were found in some subjects with no biochemical or clinical evidence of hypothyroidism and occasionally in sera from patients with unequivocal hyperthyroidism....
متن کاملHow sensitive are immunometric assays for thyrotropin?
The usual method for calculation of the "sensitivity" of thyrotropin immunometric assays is multireplicate analysis of the zero analyte standard. Although this is a statistically valid estimate of the scatter likely to be found in the response variable, it is unrelated to normal analytical practice (usually analysis in duplicate) and estimates intra-assay errors only. This study was designed to...
متن کاملA thyrotropin radioimmunoassay kit evaluated vs two reference assays.
We evaluated a double-antibody radioimmunoassay kit for thyrotropin that includes calibrators prepared in a matrix of human serum and involves overnight nonequilibrium. Results were compared with those from two reference assays for thyrotropin. The range of within-assay CVs for the kit for thyrotropin values between 0.9 and 2.4 milli-int. units/L was 2.2 to 5.3%, that for between-assay CVs was ...
متن کاملCurrent status and performance goals for serum thyrotropin (TSH) assays.
Current medical needs dictate that laboratories offer thyrotropin (TSH) assays that can reliably measure low TSH concentrations--a prerequisite for using the more cost-effective TSH-centered strategy currently recommended by the American Thyroid Association. This study reviews the functional performance of the TSH immunometric assay methods currently used in clinical practice. Methodological di...
متن کاملFour sensitive thyrotropin assays critically evaluated and compared.
We compared four sensitive procedures for thyrotropin (TSH)--Corning's Magic-Lite, ElectroNucleonics' Delfia, Baxter's Stratus, Nichols' Allegro--for their ability to completely discriminate TSH concentrations in sera in euthyroidism, hyperthyroidism, and hypothyroidism. We evaluated the analytical and clinical performance of these procedures according to previously published criteria. All proc...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1998
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/44.12.2557